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  • Trimethyl Orthoformate

Trimethyl Orthoformate

Trimethyl Orthoformate, with the chemical formula HC(OCH₃)₃, is an important organic synthetic intermediate and formylation reagent. It appears as a colorless transparent liquid with a characteristic pungent odor. This compound is highly sensitive to moisture and rapidly hydrolyzes to methanol and methyl formate upon contact with water. It is primarily used in organic synthesis to introduce a formyl group or to protect alcohol hydroxyl groups. It is a key raw material in the synthesis of fine chemicals such as pharmaceuticals, pesticides, and dyes, offering high reactivity and selectivity.
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Product Parameters


Product Name (English)Trimethyl Orthoformate
CAS No.149-73-5
Physical Properties- Colorless transparent liquid with a distinctive, pungent odor
- Sensitive to moisture, hydrolyzes in water
- Good solvent for many organic compounds
- Relatively low boiling point
Applications- Key protecting agent and synthetic intermediate in pharmaceutical industry
- Building block in pesticide synthesis
- Used in the synthesis of vitamins and dyes
- Organic synthesis reagent (e.g., for preparing acetals)
SpecificationsPurity: ≥99.0%
Boiling Point: 103-105°C
Density: 0.967-0.971 g/cm³ (20°C)
Refractive Index: 1.379 - 1.381 (20°C)
Acidity (as HCOOH): ≤0.1%
Packaging200 KG/drum (stainless steel or epoxy-lined carbon steel, ensuring moisture-proof)

Basic Properties


  1. Physical Properties:
    · Appearance: Colorless transparent liquid with pungent odor
    · Melting Point: <-50°C
    · Boiling Point: 103-105°C
    · Density: 0.967-0.971 g/cm³ (20°C)
    · Solubility: Reacts with water; miscible with ethanol, ether, acetone and most organic solvents
    · Refractive Index: 1.379 - 1.381 (20°C)

  2. Chemical Properties:
    · Extremely moisture-sensitive, which is its key chemical characteristic
    · Undergoes hydrolysis in water: HC(OCH₃)₃ + H₂O → HCOOCH₃ + 2CH₃OH
    · Can undergo alkoxy group exchange with alcohols
    · Serves as a formylating agent for the synthesis of acetals, Vitamin B1, pyridine dyes, etc.
    · Reacts with Grignard reagents to form aldehydes

Main Applications


  1. Pharmaceutical Industry: Used as a key intermediate and protecting agent in the synthesis of various antibiotics, antimalarials, antivirals, and vitamins (e.g., Vitamin B1).

  2. Pesticide Synthesis: Used in the production of high-efficiency insecticides, fungicides, and herbicides.

  3. Dye Industry: Used as a formylating agent in the synthesis of various pyridine and cyanine dyes.

  4. Organic Synthesis: Used for the synthesis of organic compounds like acetals and enol ethers; serves as a formyl source in various reactions.

  5. Other Fields: Used in fragrance synthesis and as a specialty solvent.

Safety Precautions


  1. Health Hazards:
    · Causes severe skin, eye and respiratory tract irritation
    · Inhalation of vapor may cause coughing, sore throat, shortness of breath, and central nervous system depression (dizziness, headache, drowsiness)
    · Harmful if swallowed; may cause severe irritation and damage to the digestive tract
    · Hydrolysis product methanol is toxic

  2. Handling Protection:
    · Must be handled in a dry, well-ventilated area. Prevent contact with water vapor.
    · Wear chemical safety goggles, chemical-resistant gloves and protective clothing
    · Use respiratory protection effective against organic vapors
    · Strictly avoid contact with skin, eyes and clothing
    · Do not eat, drink or smoke in work area

  3. Storage & Transportation:
    · Store in a cool, dry, well-ventilated place. Keep containers tightly sealed.
    · Protect from hydrolysis by using desiccants or an inert atmosphere (e.g., nitrogen)
    · Keep away from heat, sparks, open flames and hot surfaces
    · Store separately from strong oxidizers, strong acids, strong bases, water and moisture
    · Containers must be properly grounded to prevent static accumulation
    · Packaging must be absolutely moisture-proof (epoxy-lined steel or stainless steel drums recommended)

  4. Fire Fighting:
    · Flammable liquid, flash point ~15°C (closed cup)
    · Vapor can form explosive mixture with air
    · Use dry powder, CO2, or alcohol-resistant foam to extinguish fire
    · Do NOT use water as it will cause a vigorous reaction
    · Firefighters must wear self-contained breathing apparatus and full protective gear

Company Profile

Junteng Chemical is a professional chemical raw materials trading company dedicated to providing customers with one-stop procurement services. Through strict supplier, supply chain, and after-sales management, the company ensures that product quality, transportation, and use meet customer needs. Furthermore, the company's technical team offers customized solutions and support services free of charge.

 

The company has projects in the pharmaceutical, pesticide, petrochemical, construction, food additives, wastewater treatment, adhesives, inks, paints, coatings, plastic and rubber processing, detergent raw materials, fertilizer and textile mills, and more. Junteng Chemical sources products of stable and reliable quality, collaborating with domestic and international companies such as Luxi Group, Weiyuan Chemical, Qilu Petrochemical, Dongying Lihuayi, Yanshan Petrochemical, Sinopec, Shijiazhuang Refinery, Qingdao Petrochemical, Sailboat, Dow Chemical, BASF, South Korea, Taiwan, and Saudi Arabia. Our stable supply, superior product quality, and mature logistics have earned us a wide clientele. We look forward to collaborating with all of you for a mutually beneficial future.

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Company advantages

1

One-Stop Procurement
Platform

We integrate resources across all productcategories, including organic solvents,resins and rubbers, and inorganicchemicals,and strictly control suppliers.supply chains, and after-sales processes toensure stable quality, efficienttransportation,and worry-free use,simplifying your procurement process.

2

Professional Team TechnicalEmpowerment

Equipped with an experienced technicalteam, we provide free personalizedsolutions and professional technicalsupport to customers in varlous industrie,such as pharmaceuticals, petrochemicals,coatings and inks, and sewage treatment,.helping you solve problems and improveefficiency.

3

Global supply ChainSecurity

We work with top domestic and foreignchemical giants such as Luxi Group, QiluPetrochemical, Sinopec, BASF of Germany,and Dow of the United States to establisha stable and reliable high-quality supplynetwork and a mature logistics system toensure timely and safe delivery of
products.

4

Deep Win-Win CooperationConcept

Adhering to the concept of "integrity.immediate action, professionalism,innovation and win-win" and taking"customer success and altruism" as ourmission, we are committed to establishinglong-term strategic partnerships andcreating a better future through excellentproducts and services.

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