Triethyl Orthoformate

Triethyl Orthoformate, with the chemical formula HC(OC₂H₅)₃, is a vital organic synthetic intermediate and orthoester. It appears as a colorless transparent liquid with a characteristic pungent odor. This compound is extremely moisture-sensitive and rapidly hydrolyzes to ethanol and ethyl formate upon contact with water. It is widely used in organic synthesis to introduce ethoxy groups or to protect aldehyde and hydroxyl groups. It is a key raw material in the production of fine chemicals such as pharmaceuticals, agrochemicals, dyes, and fragrances, known for its high reactivity and selectivity.
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Product Parameters


Product Name (English)Triethyl Orthoformate
CAS No.122-51-0
Physical Properties- Colorless transparent liquid with a characteristic, pungent odor
- Highly sensitive to moisture, hydrolyzes in contact with water
- Good solvent for various organic compounds
Applications- Key protecting agent and synthetic building block in pharmaceutical industry
- Intermediate in the synthesis of pesticides and dyes
- Used in the preparation of vinyl ethers and other organic compounds
- Crosslinking agent in polymer chemistry
SpecificationsPurity: ≥99.0%
Boiling Point: 145-146°C
Density: 0.890-0.895 g/cm³ (20°C)
Refractive Index: 1.390 - 1.392 (20°C)
Acidity (as HCOOH): ≤0.1%
Packaging200 KG/drum (tightly sealed, moisture-proof packaging such as galvanized iron or epoxy-lined steel drums)

Basic Properties


  1. Physical Properties:
    · Appearance: Colorless transparent liquid with pungent odor
    · Melting Point: <-70°C
    · Boiling Point: 145-146°C
    · Density: 0.890-0.895 g/cm³ (20°C)
    · Solubility: Reacts vigorously with water; miscible with ethanol, ether, acetone and most organic solvents
    · Refractive Index: 1.390 - 1.392 (20°C)

  2. Chemical Properties:
    · Key chemical characteristic: Highly moisture-sensitive, prone to hydrolysis
    · Hydrolysis: HC(OC₂H₅)₃ + H₂O → HCOOC₂H₅ + 2C₂H₅OH
    · Can undergo exchange reactions with alcohols to form mixed orthoesters
    · Serves as an ethylating agent and a formyl equivalent, widely used in the synthesis of heterocyclic compounds (e.g., pyridines, pyrimidines)
    · Used in the synthesis of enol ethers, vinyl ethers, and dyes
    · Reacts with Grignard reagents to form aldehydes

Main Applications


  1. Pharmaceutical Industry: Used as a key intermediate in the synthesis of various antibiotics (e.g., chloramphenicol), antimalarials, anxiolytics, and vitamins.

  2. Agrochemical Synthesis: Used in the production of high-efficiency insecticides, fungicides, and herbicides (e.g., imidacloprid and other pyridine-based pesticides).

  3. Dye Industry: Serves as an important intermediate for the synthesis of cyanine dyes and other various dyes.

  4. Organic Synthesis: Used for the synthesis of enol ethers and vinyl ethers; acts as a protecting group for aldehydes and alcohols; serves as a formyl source.

  5. Other Fields: Used in fragrance synthesis and as a specialty solvent. Used as a crosslinking agent in polymer chemistry.

Safety Precautions


  1. Health Hazards:
    · Causes severe irritation to skin, eyes and respiratory tract
    · Inhalation of vapor may cause coughing, sore throat, shortness of breath, and central nervous system depression (dizziness, headache)
    · Harmful if swallowed; may cause severe irritation and damage to the digestive tract
    · Hydrolysis products (ethanol and ethyl formate) also possess certain toxicity and irritancy

  2. Handling Protection:
    · Must be handled in a dry, well-ventilated area. Strictly prevent contact with water or moisture.
    · Wear chemical safety goggles, chemical-resistant gloves and protective clothing
    · Use respiratory protection effective against organic vapors
    · Strictly avoid contact with skin, eyes and clothing
    · Do not eat, drink or smoke in work area

  3. Storage & Transportation:
    · Store in a cool, dry, well-ventilated, explosion-proof area. Keep containers tightly sealed.
    · Preferably seal under an inert atmosphere (e.g., dry nitrogen) to prevent hydrolysis and deterioration
    · Keep away from heat, sparks, open flames and hot surfaces
    · Store separately from strong oxidizers, strong acids, strong bases, water and moisture
    · Containers must be properly grounded to prevent static accumulation
    · Packaging must be absolutely moisture-proof (galvanized iron or epoxy-lined steel drums recommended)

  4. Fire Fighting:
    · Flammable liquid, flash point ~30°C (closed cup)
    · Vapor can form explosive mixture with air
    · Use dry powder, CO2, or alcohol-resistant foam to extinguish fire
    · Do NOT use water as it will cause a vigorous reaction and may spread the fire
    · Firefighters must wear self-contained breathing apparatus and full protective gear

Company Profile

Junteng Chemical is a professional chemical raw materials trading company dedicated to providing customers with one-stop procurement services. Through strict supplier, supply chain, and after-sales management, the company ensures that product quality, transportation, and use meet customer needs. Furthermore, the company's technical team offers customized solutions and support services free of charge.

 

The company has projects in the pharmaceutical, pesticide, petrochemical, construction, food additives, wastewater treatment, adhesives, inks, paints, coatings, plastic and rubber processing, detergent raw materials, fertilizer and textile mills, and more. Junteng Chemical sources products of stable and reliable quality, collaborating with domestic and international companies such as Luxi Group, Weiyuan Chemical, Qilu Petrochemical, Dongying Lihuayi, Yanshan Petrochemical, Sinopec, Shijiazhuang Refinery, Qingdao Petrochemical, Sailboat, Dow Chemical, BASF, South Korea, Taiwan, and Saudi Arabia. Our stable supply, superior product quality, and mature logistics have earned us a wide clientele. We look forward to collaborating with all of you for a mutually beneficial future.

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Company advantages

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One-Stop Procurement
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We integrate resources across all productcategories, including organic solvents,resins and rubbers, and inorganicchemicals,and strictly control suppliers.supply chains, and after-sales processes toensure stable quality, efficienttransportation,and worry-free use,simplifying your procurement process.

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Professional Team TechnicalEmpowerment

Equipped with an experienced technicalteam, we provide free personalizedsolutions and professional technicalsupport to customers in varlous industrie,such as pharmaceuticals, petrochemicals,coatings and inks, and sewage treatment,.helping you solve problems and improveefficiency.

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Global supply ChainSecurity

We work with top domestic and foreignchemical giants such as Luxi Group, QiluPetrochemical, Sinopec, BASF of Germany,and Dow of the United States to establisha stable and reliable high-quality supplynetwork and a mature logistics system toensure timely and safe delivery of
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