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  • Trimethyl Orthoformate
  • Trimethyl Orthoformate
  • Trimethyl Orthoformate

Trimethyl Orthoformate

Trimethyl Orthoformate, with the chemical formula HC(OCH₃)₃, is an important reagent and intermediate in organic synthesis. It appears as a colorless transparent liquid with a characteristic pungent odor. It hydrolyzes rapidly in moist air to form methanol and methyl formate. The molecule contains three methoxy groups, making it highly reactive. It is extensively used in the synthesis of fine chemicals such as pharmaceuticals, agrochemicals, and dyes, commonly employed for introducing methoxy groups or acting as a protecting group for the formyl group.
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Product Parameters


Product Name (English)Trimethyl Orthoformate
CAS No.149-73-5
Physical Properties- Colorless transparent liquid with a characteristic pungent odor
- Highly reactive, hydrolyzes rapidly in contact with water, releasing methanol
- Important organic synthetic reagent and intermediate
Applications- Key reagent in organic synthesis (e.g., introduction of methoxy group, protection of formyl group)
- Used in the synthesis of pharmaceuticals, dyes, and perfumes
- Intermediate for agrochemicals and vitamins
SpecificationsPurity: ≥98.0%
Boiling Point: 101-102°C
Density: 0.967-0.971 g/cm³ (20°C)
Refractive Index: 1.379-1.381 (20°C)
Acidity (as HCOOH): ≤0.1%
Packaging160 KG/drum (galvanized iron drum or stainless steel)

Basic Properties


  1. Physical Properties:
    · Appearance: Colorless transparent liquid with a pungent odor
    · Melting Point: <-50°C
    · Boiling Point: 101-102°C
    · Density: 0.967-0.971 g/cm³ (20°C)
    · Solubility: Miscible with ethanol, ether, benzene and other organic solvents; decomposes rapidly in water
    · Refractive Index: 1.379-1.381 (20°C)

  2. Chemical Properties:
    · Highly susceptible to hydrolysis, especially under acidic conditions, to form formate esters and methanol
    · Reacts with Grignard reagents to produce aldehydes
    · Commonly used in condensation, alkylation, and protection reactions in organic synthesis
    · Sensitive to oxidizers

Main Applications


  1. Pharmaceutical Synthesis: Used as a key intermediate in the synthesis of various drugs, particularly vitamins (e.g., Vitamin B1, Vitamin A), antibiotics, and antiviral agents.

  2. Agrochemical Synthesis: Used in the production of insecticides, fungicides, and herbicides.

  3. Dye Industry: Serves as a raw material for the synthesis of various dyes (e.g., cyanine dyes).

  4. Fragrance Industry: Used in the synthesis of certain flavors and fragrances.

  5. Organic Synthesis: Widely used in both laboratory and industrial-scale organic synthesis for introducing methoxy groups, protecting aldehyde groups, and synthesizing heterocyclic compounds.

Safety Precautions


  1. Health Hazards:
    · Causes severe skin, eye and respiratory tract irritation
    · Inhalation of vapor may cause coughing, sore throat, respiratory distress and central nervous system depression
    · Harmful if swallowed, causes severe irritation and damage to the digestive tract
    · May cause effects on the nervous system at high exposure levels

  2. Handling Protection:
    · Handle only in a fume hood or with excellent ventilation.
    · Wear chemical safety goggles, chemical-resistant gloves and protective clothing.
    · Avoid contact with eyes, skin and clothing.
    · Wash hands thoroughly after handling.

  3. Storage & Transportation:
    · Store in a cool, dry, well-ventilated place away from heat and ignition sources.
    · Keep container tightly closed and under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and hydrolysis.
    · Store separately from strong acids, strong oxidizing agents, and water.
    · Containers must be grounded to prevent static electricity accumulation.

  4. Fire Fighting:
    · Highly flammable liquid, flash point approx. 15°C (open cup)
    · Vapor can form an explosive mixture with air.
    · Use alcohol-resistant foam, dry powder, or carbon dioxide to extinguish.
    · Firefighters must wear self-contained breathing apparatus and full protective gear.

Company Profile

Junteng Chemical is a professional chemical raw materials trading company dedicated to providing customers with one-stop procurement services. Through strict supplier, supply chain, and after-sales management, the company ensures that product quality, transportation, and use meet customer needs. Furthermore, the company's technical team offers customized solutions and support services free of charge.

 

The company has projects in the pharmaceutical, pesticide, petrochemical, construction, food additives, wastewater treatment, adhesives, inks, paints, coatings, plastic and rubber processing, detergent raw materials, fertilizer and textile mills, and more. Junteng Chemical sources products of stable and reliable quality, collaborating with domestic and international companies such as Luxi Group, Weiyuan Chemical, Qilu Petrochemical, Dongying Lihuayi, Yanshan Petrochemical, Sinopec, Shijiazhuang Refinery, Qingdao Petrochemical, Sailboat, Dow Chemical, BASF, South Korea, Taiwan, and Saudi Arabia. Our stable supply, superior product quality, and mature logistics have earned us a wide clientele. We look forward to collaborating with all of you for a mutually beneficial future.

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Company advantages

1

One-Stop Procurement
Platform

We integrate resources across all productcategories, including organic solvents,resins and rubbers, and inorganicchemicals,and strictly control suppliers.supply chains, and after-sales processes toensure stable quality, efficienttransportation,and worry-free use,simplifying your procurement process.

2

Professional Team TechnicalEmpowerment

Equipped with an experienced technicalteam, we provide free personalizedsolutions and professional technicalsupport to customers in varlous industrie,such as pharmaceuticals, petrochemicals,coatings and inks, and sewage treatment,.helping you solve problems and improveefficiency.

3

Global supply ChainSecurity

We work with top domestic and foreignchemical giants such as Luxi Group, QiluPetrochemical, Sinopec, BASF of Germany,and Dow of the United States to establisha stable and reliable high-quality supplynetwork and a mature logistics system toensure timely and safe delivery of
products.

4

Deep Win-Win CooperationConcept

Adhering to the concept of "integrity.immediate action, professionalism,innovation and win-win" and taking"customer success and altruism" as ourmission, we are committed to establishinglong-term strategic partnerships andcreating a better future through excellentproducts and services.

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